Spravato®
Understanding Spravato®
A Whole-Person Perspective
For some individuals, depression does not improve despite trying multiple
antidepressants and therapies. This is known as treatment-resistant depression
(TRD) — a condition that can feel frustrating, exhausting, and isolating.
Spravato® (esketamine), an FDA-approved nasal spray, offers a new pathway to relief for adults with TRD and for those experiencing major depressive disorder (MDD) with suicidal thoughts or actions. Unlike traditional antidepressants, Spravato works on different brain pathways and can provide rapid improvement in mood for many patients.
At Integrative Psychiatric Services (IPS), we provide Spravato within a comprehensive treatment plan, combining clinical expertise with compassionate care in a safe, supportive setting.
Spravato® (esketamine), an FDA-approved nasal spray, offers a new pathway to relief for adults with TRD and for those experiencing major depressive disorder (MDD) with suicidal thoughts or actions. Unlike traditional antidepressants, Spravato works on different brain pathways and can provide rapid improvement in mood for many patients.
At Integrative Psychiatric Services (IPS), we provide Spravato within a comprehensive treatment plan, combining clinical expertise with compassionate care in a safe, supportive setting.
Spravato in America: Fast Facts
- Approved by the FDA in 2019 for treatment-resistant depression and depressive symptoms in adults with suicidal thoughts or behaviors.
- Works differently from traditional antidepressants, targeting the brain’s NMDA receptors and increasing glutamate activity.
- Clinical studies show that some patients experience improvement within hours to days, compared to the weeks traditional antidepressants may take.
- Must be administered in a certified medical office under supervision; cannot be taken at home.
How Spravato Works
Spravato targets the NMDA receptor system in the brain, increasing glutamate — a
neurotransmitter involved in mood regulation and neuroplasticity. This action can:
- Rapidly reduce depressive symptoms
- Improve emotional regulation and motivation
- Enhance brain connectivity and flexibility in response to stress
Who is Spravato For?
Spravato may be considered for adults who:
- Have tried at least two different antidepressants without adequate improvement
- Have major depressive disorder with suicidal thoughts or behaviors
- Need a faster-acting option due to severity of symptoms
The Spravato Process at IPS
We provide Spravato in a comfortable, private, and medically monitored
environment:
- Pre-treatment check-in – Review symptoms, mood, and readiness.
- Administration – You self-administer the nasal spray under a clinician’s guidance.
- Observation period – You rest for about two hours while our team monitors your vitals and safety.
- Post-treatment debrief – We discuss your experience and next steps.
Because Spravato can cause temporary side effects such as dizziness or feeling
“spaced out,” you will need a ride home after each session.
Typical Treatment Schedule
- Weeks 1–4: Twice weekly
- Weeks 5–8: Once weekly
- Week 9 onward: Every 1–2 weeks for maintenance, based on progress
Possible Side Effects
Most side effects are temporary and monitored closely during each session:
- Dizziness or lightheadedness
- Nausea
- Temporary changes in perception or dissociation
- Mild increase in blood pressure
Why Choose IPS for Spravato?
- Specialized Expertise: Experienced clinicians trained in esketamine therapy.
- Whole-Person Care: We integrate Spravato with psychotherapy, medication management, and lifestyle interventions.
- Collaborative Approach: We coordinate with your existing providers to ensure continuity of care.
Moving Forward with Hope
Treatment-resistant depression can feel like a closed door, but Spravato offers a new
way forward. Many patients describe feeling their mood lift for the first time in years.
At IPS, we’re committed to guiding you through every step — with science-based care, compassion, and a shared belief that recovery is possible
At IPS, we’re committed to guiding you through every step — with science-based care, compassion, and a shared belief that recovery is possible
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